However, many modern, non-infectious chronic illnesses – the so-called ‘diseases of civilisation’ – do not fit the ‘one gene, one disease’ paradigm. The explosion of knowledge in genetics led to the discovery of many diseases that resulted from single genetic mutations. In the 21st century, acute infectious diseases have been replaced by cardiovascular disease (CVD), cancer and diabetic complications as the most common causes of death. As a result of improved public sanitation and breakthrough developments in antimicrobial agents, these once formidable illnesses are now more rare and easily treated. The top three causes of death were pneumonia, tuberculosis and gastrointestinal infections. This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution,Īnd reproduction in any medium, provided the original work is properly cited.Īt the beginning of the 20th century, infectious agents were the major causes of disease. Hyperinsulinemia and Insulin Resistance: Scope of the ProblemĬopyright: © 2016. Hyperinsulinemia and Insulin Resistance: Scope of the Problem.
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